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J Intellect Disabil Res 2007;51(Pt 4):302–11. 131. Hoybye C. Five-years growth hormone (GH) treatment in adults with Prader-Willi syndrome. Acta Paediatr 2007;96(3):410–3. 132. Eiholzer U, Grieser J, Schlumpf M, et al. Clinical effects of treatment for hypogonadism in male adolescents with Prader-Labhart-Willi syndrome. Horm Res 2007;68(4):178–84. 133. Ogura K, Shinohara M, Ohno K, et al. Frontal behavioral syndromes in PraderWilli syndrome. Brain Dev 2008;30(7):469–76. 134. Zarcone J, Napolitano D, Peterson C, et al.

50. Hagerman R. Clinical and molecular aspects of fragile X syndrome. In: TagerFlusberg H, editor. Neurodevelopmental disorders. Cambridge (MA): MIT Press; 1999. p. 27–42. 51. Hagerman PJ, Hagerman RJ. The fragile X premuation: a maturing perspective. Am J Hum Genet 2004;75:805–16. 52. Rousseau F, Rouillard P, Morel ML, et al. Prevalence of carriers of premutationsize alleles of the FMR1 gene-and implications for the populaton genetics of the fragile X syndrome. Am J Hum Genet 1995;57:1006–18. 53.

ADHD is a disorder with strong neurobiological underpinnings. In a meta-analysis, Faraone and colleagues17 estimated the heritability of ADHD to be approximately 76%. 23,24 HOW DOES ATTENTION DEFICIT/HYPERACTIVITY DISORDER TYPICALLY PRESENT IN THE PEDIATRIC POPULATION? 25 Inattention becomes more apparent during the school-aged years Pediatric ADHD for the General Psychiatrist because of increased academic demands, although hyperactive and impulsive behaviors frequently persist. 26 These symptoms may change over time in presentation, in fact persisting as excessive talking, avoidance of situations requiring sitting quietly, recklessness, risk-taking, and poor decision making.

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