By Alton Meister
Advances in Enzymology and similar components of Molecular Biology is a seminal sequence within the box of biochemistry, providing researchers entry to authoritative reports of the most recent discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, delivering an unmatched view of the old improvement of enzymology. The sequence bargains researchers the newest realizing of enzymes, their mechanisms, reactions and evolution, roles in complicated organic technique, and their software in either the laboratory and undefined. every one quantity within the sequence gains contributions via top pioneers and investigators within the box from all over the world. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.
With its wide selection of themes and lengthy historic pedigree, Advances in Enzymology and similar parts of Molecular Biology can be utilized not just by means of scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition by means of any scientist drawn to the invention of an enzyme, its houses, and its applications.
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Extra resources for Advances in Enzymology and Related Areas of Molecular Biology, Volume 53
In the “dynamic receptor affinity model” of Williams and Lefkowitz (68), a ternary complex HRE, including the agonist, the receptor, and the enzyme itself, was considered both as the high-affinity form of the receptor and as the precursor of the active form of the enzyme (68). However, the ability t o dissociate the process of formation of the high-affinity form of the receptor from the catalytic component o f the system b y MnZ+(42) or N-ethylmaleimide (48) suggests that the high-affinity form of the receptor incorporates the nucleotide regulatory protein HRN rather than the catalytic component itself.
This model, however, also fails t o predict the agonist-specific binding properties described earlier. The agonistpromoted transition of the R N oligomer complex involves a conformational change without any change in the composition of the complex itself. Such a reaction cannot account for the observation of the high- and lowaffinity forms of agonist-receptor complex described in a preceding section. The dissaggregation coupling model also fails t o accommodate the observation of the presence of the nucleotide binding protein exclusively in agonist-prelabeled and not in antagonist-prelabeled soluble receptor preparations (132).
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