Download Amyotrophic Lateral Sclerosis: A Synthesis of Research and by Andrew Eisen, Charles Krieger PDF

By Andrew Eisen, Charles Krieger

Amyotrophic Lateral Sclerosis, differently referred to as Lou Gehrig's ailment, is one of the degenerative ailments of the getting older fearful approach. this article smartly synthesizes the new explosion of analysis into this actual situation to build a close and complete evaluate. Drs. Eisen and Krieger convey their examine services and broad medical adventure to supply this functional and thought-provoking account. Chapters hide the epidemiology, molecular biology, and pathophysiology of ALS, in addition to matters pertinent to medical evaluate and care.

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7. Kaplan-Meier survival curves by sex (top) and age (bottom). The survival curves are not significantly different for men and women. Age has a significant effect on survival of ALS, with patients who have a young onset living longer. 02). 0001). (From Eisen et al. (1993b). Muscle & Nerve, 16; 27-32. 2. 4 Percentile After Eisen et al (1993c). 2). Even though disease duration in young women also appears longer than in other age groups, the numbers were too few for the difference to reach statistical significance.

Those that have raised the greatest interest include: lead, mercury, copper, iron, aluminium, calcium, magnesium, manganese and selenium. Removal of lead and other putative toxic substances by the use of chelation therapy has not been beneficial in ALS. However, if metal intoxication plays a role in ALS, the damage it induces is likely to be irreversible by the time symptoms have developed. Measurements of serum, cerebrospinal fluid, muscle and brain concentrations of most Risk factors for developing ALS 17 metals have not been different in ALS patients compared to normal controls.

It is probable that by the time clinical deficits appear and the diagnosis is more evident, the possibility of reversing the progression of the disease is less feasible. Diagnosis of ALS during the pre-symptomatic period must await the identification of a biochemical or other biological marker for ALS with proven specificity and sensitivity that has been assessed in prospective studies. Once the disease has been present for a few months, the diagnosis of ALS can usually be made with a reasonable degree of confidence and is normally straightforward.

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