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By Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham

The swift velocity of evolution in domino, or cascade-based adjustments has revolutionized the perform of chemical synthesis for the construction of average items, designed molecules, and pharmaceuticals.


"Science of Synthesis: purposes of Domino differences in natural Synthesis" explores the subject completely and systematically, serving because the foundation for useful purposes and destiny examine. The 2-volume set offers the state-of-the-art when it comes to layout, process, and experimental methods, resulting in a number of occasions being entire inside of a unmarried response vessel. The content material is geared up via the center form of response used to start up the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 2 covers pericyclic reactions (Diels-Alder, sigmatropic shifts, ene reactions), dearomatizations, and additions to C-O/C-N a number of bonds.

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Extra info for Applications of domino transformations in organic synthesis 2

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1 The Diels–Alder Cycloaddition Reaction in the Context of Domino Processes J. G. West and E. J. Sorensen General Introduction The title that Otto Diels and Kurt Alder chose for their 1928 publication, “Syntheses in the Hydroaromatic Series”, in Annalen[1] did not signal the revolution that their new insights would bring to the field of organic chemistry. ” The very next sentence, “We explicitly reserve for ourselves the application of the reaction discovered by us to the solution of such problems”, is even more colorful, but, in reality, nearly a quarter of a century would pass before the power of the “Diels–Alder” reaction was demonstrated in the context of natural product synthesis.

5),[35] it was recognized that the sophisticated decahydrofluorene subunit of the target can be accessed from a Diels–Alder union of a trienic diene with its pendent Æ,â-unsaturated ketone. 1 Pericyclic Reactions team to take place during a domino process whereby the unique architecture of the target would be assembled from a trisubstituted cyclohexane starting material.

9 Iminium-Catalyzed Michael/Morita–Baylis–Hillman Reactions . . . . . . . . 10 Iminium-Catalyzed Michael/Hemiacetalization Reactions . . . . . . . . . . 2 Thiourea-Catalyzed Domino Addition to C=O Bonds . . . . . . . . . . . . 1 Aldol/Cyclization Reactions . . . . . . . . . . . . . . . . . . . . . . . . 2 Michael/Aldol Reactions . . . . . . . . . . . . . . . . . . . . . . . . . 3 Michael/Henry Reactions . . . . . . .

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