Download Asymmetric synthesis in organophosphorus chemistry: by Oleg I. Kolodiazhnyi PDF

By Oleg I. Kolodiazhnyi

Authored through one of many major specialists within the box, this is often the one accomplished evaluate of chiral organophosphorus compounds, from uneven synthesis to catalysis and pharmacological applications.
As such, this precise reference covers the chemical history in addition to spectroscopical research of phosphorus compounds, and punctiliously describes all of the a number of artificial thoughts for those ingredients. Metal-, organo- and biocatalyzed reactions for the advent of phosphorus are defined as are uneven oxidation and aid equipment for the coaching of all attainable oxidation states of phosphorus. The textual content additionally comprises business functions for those compounds.
Of specific curiosity to chemists operating within the box of uneven synthesis, in addition to to the pharmaceutical end result of the expanding variety of phosphorous-containing medications

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Extra info for Asymmetric synthesis in organophosphorus chemistry: synthetic methods, catalysis, and applications

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M. H. (1972) Shift reagents in NMR spectroscopy. Nature, 240, 385–390. J. E. (1975) Preparation of an optically active prostaglandin intermediate via asymmetric induction. J. Am. Chem. , 97 (23), 6908–6909. Kunz, H. (2005) Leopold Horner (1911–2005): Nestor of preparative organic chemistry. Angew. Chem. Int. , 44 (47), 7664–7665. (a) Horner, L. (1980) Dreibindige, optisch aktive Phosphorverbindungen, ihre Synthese, chemische Eigenschaften und Bedeutung fur die asymmetrische Homogenhydrierung. Pure Appl.

Separation of enantiomers of axially dissymmetric 1,3-bis(2,4,6-tri-tbutylphenyl)-l,3-diphospha-allene 9 was attained by high performance liquid chromatography (HPLC) with a chiral (+)-poly(triphenylmethy1 methacrylate) column [16]. The absolute configuration of the optically pure (−)-phospha-allene 9 was determined by means of circular dichroism (CD) spectra. 7). These phenomena are very similar to those observed for the systems of double-bonded phosphorus compounds in low coordination state such as diphosphaallene which resulted in racemization on photolysis or diphosphenes and phosphaethylenes of Dh symmetry which resulted in isomerization on photolysis.

1997)Chiral Separations: Application and Technology, American Chemical Society, Washington, DC. , and Principato, G. (1998) Separation of the enantiomers of a-hydroxybenzylphosphonate esters by enantioselective HPLC and determination of their absolute configuration by circular dichroism. Chirality, 10 (1-2), 100–105. H. C. (1989) Considerations of chiral recognition relevant to the liquid chromatography separation of enantiomers. Chem. , 89 (2), 347–362. M. (1980) Broad spectrum resolution of optical isomers using chiral high-performance liquid chromatographic bonded phases.

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