By Dr. Hans Wolfgang Kölmel (auth.)
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Extra info for Atlas of Cerebrospinal Fluid Cells
They perform specific tasks in the course of infectious disorders and occasionally appear in large numbers after cerebral Plate 6 a, b Patient: female, 4 weeks old. Cerebral trauma at delivery. CSF: 120 cells/mm 3 . Loose, undifferentiated leptomeningeal cell clusters. c, d Same patient: 2 weeks later. CSF: 430 cells/ mm 3 • 120 mg% protein. The leptomeningeal stem cells have developed for the most part into macrophages, some of which show degenerative stigmata. 24 stroke . Their primary function is the elimination of foreign matter by means of phagocytosis.
Staining with Prussian blue provides the only definitive evidence of hemosiderin in the cytoplasm. The hematogenous pigments take on various shades of blue with this stain, which provides the only certain differentiation between phagocytized melanin and hemosiderin. In melanoma metastases of the CNS, the phagocytes are capable of depositing both hemosiderin and melanin in the cytoplasm. d c f e 33 4. Eosinophilic Granulocytes Eosinophils can easily be recognized in panoptically stained slide preparations on the basis of their relatively large eosinophilic plasma granules.
Patient: male, 40 years old. CSF: 60 cells/ mm 3 , 20% eosinophils. b Eosinophils in tuberculous meningoencephalitis. Patient: male, 25 years old. CSF: 250 cells/ mm 3 , 6% eosinophils. c "Foreign body" meningitis after implantation of a Spitz-Holter drain. Patient: female, 3 years old. CSF: 600 cells/mm 3 , 90% eosinophils. 34 They appear most often in the cellularity that accompanies tuberculous meningitis, although not in the entire course of the disease. Eosinophils rarely predominate in meningitis .