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Extra info for Biochemistry (Lippincott Illustrated Reviews Series), 6th edition
It s hould be s ta bilize d in the ta ut, ra the r tha n the re la xe d, form. B. It s hould ha ve incre a s e d O 2 a ffinity a nd, cons e que ntly, de cre a s e d de live ry of O 2 to tis s ue s . C. Its O 2 -dis s ocia tion curve s hould be s hifte d to the right re la tive to HbA. D. It re s ults in a ne mia . 5 Why is he moglobin C dis e a s e a nons ickling dis e a s e ? Corre ct a ns we r = B. S ubs titution of lys ine by me thionine de cre a s e s the a bility of ne ga tive ly cha rge d phos pha te groups in 2,3-bis phos phoglyce ra te (2,3-BP G) to bind the β s ubunits of he moglobin.
2 Which one of the following s ta te me nts conce rning the a bility of a cidos is to pre cipita te a cris is in s ickle ce ll a ne mia is corre ct? A. Acidos is de cre a s e s the s olubility of HbS . B. Acidos is incre a s e s the a ffinity of he moglobin for O 2 . C. Acidos is fa vors the conve rs ion of he moglobin from the ta ut to the re la xe d conforma tion. D. Acidos is s hifts the oxyge n-dis s ocia tion curve to the le ft. E. Acidos is de cre a s e s the a bility of 2,3-bis phos phoglyce ra te to bind to he moglobin.
Study Ques tions Choose the ONE best answer. 1 Which one of the following s ta te me nts conce rning the he moglobins is corre ct? A. HbA is the mos t a bunda nt he moglobin in norma l adults. B. Fetal blood has a lower affinity for oxygen than does adult blood because HbF has an increased affinity for 2,3-bisphosphoglycerate. C. The globin chain composition of HbF is α 2δ2. D. HbA1c differs from HbA by a single, genetically determined amino acid substitution. E. HbA2 appears early in fetal life.