Download Biochemistry of Membrane Transport: FEBS — Symposium No. 42 by K. Mühlethaler (auth.), Professor Dr. Giorgio Semenza, PDF

By K. Mühlethaler (auth.), Professor Dr. Giorgio Semenza, Professor Dr. Ernesto Carafoli (eds.)

This quantity includes the lawsuits of the FEBS Sym­ posium at the Biochemistry of Membrane shipping, which was once held on the Swiss Institute of know-how, Zlirich, July 18-23, 1976. Of the audio system invited or­ iginally, purely 5 couldn't attend the assembly, and of the lectures given, all yet one of many texts are released right here. therefore, this quantity supplies a devoted ac­ count number of how the assembly was once initially conceived and really happened. This Symposium on Biochemistry of Membrane shipping used to be the 1st Symposium backed through the FEBS outdoor the annual FEBS-Meetings, after the certain assembly on commercial Biochemistry, which came about in Dublin in 1973, and it displays the curiosity and the fashion for gatherings of smaller measurement than the reputable FEBS conferences. the subject of the Symposium used to be a simple selection, not just simply because membrane delivery is becom­ ing progressively more very important to biochemistry each year, but additionally as a result of the long-standing curiosity of Swiss technology within the box. within the collection of the themes and of the audio system, efforts have been made to accomplish as balanced a assurance of the world as attainable. notwithstanding, considering that a few points of membrane biochemistry have been handled commonly on the parallel tenth Inter­ nationwide Congress of Biochemistry in Hamburg, GFR, cer­ tain issues got much less emphasis than others. The Symposium used to be attended via approximately four hundred contributors (we anticipated 200-250); between them forty eight have been invited audio system, and a few 2 hundred contributed posters.

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4-7. Lipid phase transition and lateral mobility of integral proteins Fig. 4a-c. DSC cooling runs of whole mitochondria (a) and purified outer membrane (b,c). 2 mCal . sec- 1 (c). Arrows identify temperatures on the curve for whole mitochondria which correspond to Figs. 5-7 Fig . 5. oconcave fracture faces of both membranes of a mitochondrion frozen from 10 C Fig. 6. Cooled to ooC, then frozen Fig. 7. Cooled to -SoC, then frozen. Note lateral displacement of integral proteins and smooth regions of gel state lipid.

Nonspecific IgG did not inhibit diffusion of integral proteins of any size. Of particular interest was the observation that at 25°C the largest integral proteins remained aggregated in both the outer half (Fig. 32) and inner half (Fig. 33) of the membrane. At 25°C the outer half of the membrane revealed virtually no integral proteins in the large patches of liquid crystalline bilayer lipid (Fig. 32). 4 nm in diameter) integral proteins (Fig. 33). Thus we determined that numerous small integral proteins can diffuse laterally in the energy-transducing membrane independent of cytochrome c oxidase.

Mg- I protein Table 2. ting or cooling runs and are ± l o C bCorrected for 6 0 C depressions induced by 50% ethylene glycol II. Studies on Whole Mitochondria DSC revealed that the transition exotherm of both whole mitochondria and the purified outer membrane fraction was biphasic with a slight onset temperature occurring at gOC and a major onset temperature occurring at 1°C (Fig. 4a,b). 2 mCal· sec-I) it was determined that the onset temperatures of the transition exotherm of whole mitochondria resulted from phase transitions occurring in the purified outer membrane (Fig.

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