By Prof. Dr. Gerhard Krauss(auth.)
Chapter 1 The rules of Gene Expression (pages 1–87):
Chapter 2 The rules of Enzyme job (pages 89–114):
Chapter three constitution and serve as of sign Pathways (pages 115–149):
Chapter four Signaling by means of Nuclear Receptors (pages 151–177):
Chapter five G Protein?Coupled sign Transmission Pathways (pages 179–229):
Chapter 6 Intracellular Messenger ingredients: “Second Messengers” (pages 231–268):
Chapter 7 Ser/Thr?Specific Protein Kinases and Protein Phosphatases (pages 269–309):
Chapter eight sign Transmission through Transmembrane Receptors with Tyrosine?Specific Protein Kinase task (pages 311–354):
Chapter nine sign Transmission through Ras Proteins (pages 355–381):
Chapter 10 Intracellular sign Transduction: The Protein Cascades of the MAP Kinase Pathways (pages 383–393):
Chapter eleven Membrane Receptors with linked Tyrosine Kinase task (pages 395–416):
Chapter 12 different Receptor sessions (pages 417–427):
Chapter thirteen rules of the mobilephone Cycle (pages 429–468):
Chapter 14 Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes (pages 469–509):
Chapter 15 Apoptosis (pages 511–532):
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Additional resources for Biochemistry of Signal Transduction and Regulation, Third Edition
The picture of the structure and function of TFIIH is thus varied and complex. TFIIH or components of it can assemble into different multiprotein complexes which perfom central functions in the cell. The mechanistic details and the regulation of the various activities have long been not understood. 4 Regulation of Eucaryotic Transcription by DNA-binding Proteins Primary controlling elements of the transcriptional activity in eucaryotes are specific DNA-binding proteins. They bind cis-acting DNA elements and have a specific influence on the initiation of transcription.
The distance between and nature of the bases in both the palindromic and the direct repeats of the recognition sequence plays an important role. It is evident that a dimeric protein would bind optimally to a twofold symmetric sequence only if the distance between the recognition elements matches the distance as determined by the protein structure. If one increases the distance by a few base pairs, a loss in cooperative binding capacity of the dimerization motifs of the protein to the rigid intervening DNA may Fig.
1999). Altogether, CTD phosphorylation has proven to be a point where many regulatory signals may converge and influence the transition from initiation to elongation, the efficiency of elongation and the maturation of the mRNA. Mechanistic details on how the various kinases cooperate and how they are regulated are however still lacking. II F mediator maturation of transcript II B II H Pol II II H phosphorylation association of further proteins II F by CDK7, CDK8, CDK9 elong. factor II H Pol II II D TBP transcript Fig.