Download Bioinformatics for beginners : genes, genomes, molecular by Supratim Choudhuri PDF

By Supratim Choudhuri

Bioinformatics for Beginners offers a coherent and pleasant remedy of bioinformatics for any scholar or scientist inside biology who has now not regularly played bioinformatic research.

The booklet discusses correct ideas had to comprehend the theoretical underpinnings of bioinformatic research, and demonstrates with examples certain research utilizing freely on hand web-based software program and publicly to be had databases. Eschewing non-essential details, the paintings makes a speciality of ideas and hands-on research and issues to many extra research options.

  • Avoids non-essential insurance but totally describes the sphere for newbies - in nearly two hundred pages of text
  • Explains the molecular foundation of evolution to put bioinformatic research in organic context
  • Provides valuable hyperlinks to the massive source of publicly to be had bioinformatic databases and research tools
  • Over a hundred figures reduction in notion discovery and representation

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Additional resources for Bioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools

Example text

Ohno proposed that the ancestors of reptiles, birds, and mammals had experienced at least one tetraploid evolution either at the stage of fish or at the stage of amphibians. Since the turn of the millennium, the modern version of Ohno’s hypothesis, known as the two rounds (2R) hypothesis, has resurfaced and gained popularity. There are disagreements regarding the stages of evolution when genome duplications took place. g. 14À16 There are, however, debates about the 2R hypothesis, but that is beyond the scope of this section.

G. g. protein binding, or a specific chromatin structure). Following the initial success of the first phase of ENCODE, initiated in 2003 to characterize 1% of the human genome, the scope of ENCODE has been broadened since 2007 to study DNA elements in the whole human genome. 44,45 Based on the analysis, about 80% of the genome was assigned some kind of genetic function, either RNAassociated or chromatin-associated. 7 kb of at least one of the biochemical events measured by ENCODE. The analysis annotated 8801 small RNA and 9640 long noncoding RNA-coding loci.

These 24 genomes included those of bacteria and eukaryotes, including Drosophila melanogaster and Caenorhabditis elegans. They found a number of functional associations. For example, MXR1 (peptide methionine sulfoxide reductase, involved in antioxidative processes) and YCL033C (function unknown) were predicted to be functionally associated by virtue of gene fusion in three species—Helicobacter pylori, Haemophilus influenzae, and Treponema pallidum— and this observation was supported by experimental results.

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