Download Bioinformatics for Beginners: Genes, Genomes, Molecular by Supratim Choudhuri PDF

By Supratim Choudhuri

Bioinformatics for newbies: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools offers a coherent and pleasant remedy of bioinformatics for any pupil or scientist inside biology who has no longer frequently played bioinformatic analysis.

The publication discusses the suitable ideas had to comprehend the theoretical underpinnings of bioinformatic research and demonstrates, with examples, distinct research utilizing freely on hand web-based software program and publicly on hand databases. Eschewing non-essential info, the paintings makes a speciality of rules and hands-on research, additionally pointing to extra learn options.

  • Avoids non-essential insurance, but absolutely describes the sphere for beginners
  • Explains the molecular foundation of evolution to put bioinformatic research in organic context
  • Provides beneficial hyperlinks to the substantial source of publicly to be had bioinformatic databases and research tools
  • Contains over a hundred figures that relief in idea discovery and representation

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Additional info for Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools

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Mercer TR, Mattick JS. Nat Struct Mol Biol 2013;20:300À7. Amaral PP, et al. Nucl Acids Res 2011;39:D146À51 (Database Issue) Tay Y, et al. Cell 2011;147:344À57. Salzman J, et al. PLoS ONE 2012;7(2):e30733. Memczak S, et al. Nature 2013;495:333À8. Hansen TB, et al. Nature 2013;495:384À8. Isom DG, et al. Proc Natl Acad Sci USA 2011;108:5260À5. Tompa P. Trends Biochem Sci 2012;37:509À16. Fussner, et al. EMBO Rep 2012;13:992À6. Phesant M, Mattick JS. Genome Res 2007;17:1245À53. Choudhuri S. In: Choudhuri S, Carlson DB, editors.

Jannaschii in the genome of the S. solfataricus. Characterization of these two paralogous gene products revealed that both are required for tRNA endonuclease activity, each complementing the other for complete j Homologous genes, or homologs, are related to each other by descent from a common ancestral gene. Homologs may or may not have the same or similar function. Therefore, the orthologs and paralogs described above are two different types of homologous genes. 3. 4 Three possible fates of duplicated genes: pseudogenization (nonfunctionalization), neofunctionalization, and subfunctionalization using cis-regulatory modules as targets of divergence.

Bioinformatics for Beginners. 27 2014 Published by Elsevier Inc. 28 2. FUNDAMENTALS OF MOLECULAR EVOLUTION evolution is evolution at the level of nucleic acids and proteins. At the molecular level, the primary cause of evolution is the accumulation of changes in genomic sequence (hence proteins as wellb). Therefore, evolution results in alteration of the genetic composition (gene pool) of a population over time. Changes in gene pool are associated with changes in gene frequency in a populationc.

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