By W.P. Kaschka, D. Rujescu, W.F. Gattaz
Suicide is without doubt one of the most crucial explanations of loss of life in sleek societies. To enhance more desirable preventive measures, we need to concentrate on and research extra approximately its neurobiological foundations. lately, the instruments of recent neurosciences have more and more been applied to symbolize the pathophysiology of complicated human behaviors corresponding to suicide. to enhance suicide possibility evaluation and suicide prevention, a greater knowing of its pathophysiology is important. This comprises examine from numerous disciplines resembling neuropsychological, psychosocial and cultural reports but in addition findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. very important effects have, for instance, been bought within the box of gene-environment interplay and suicidal habit. we've got simply all started to appreciate how early-life adversity could bring up suicide danger through epigenetic mechanisms. in response to such insights, novel healing interventions and preventive measures will be constructed. in addition, a greater knowing of the pathophysiological mechanisms interested by suicidal habit may demonstrate the mechanism of compounds like lithium salts. during this publication, suicidal habit and its prevention is mentioned via foreign specialists within the gentle of the latest effects from a wide spectrum of neurosciences.
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Extra resources for Biological Aspects of Suicidal Behavior
In these brains, 5-HT2C receptor isoforms with reduced functions are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic serotonin is defective . An examination of the efficiencies of RNA editing of the 5-HT2C receptor in the PFC of control individuals versus subjects diagnosed with schizophrenia or MDD revealed no significant differences in RNA editing among the three populations. However, subjects who committed suicide exhibited a significant elevation of editing at the A site, which is predicted to change the amino acid sequence in the second intracellular loop of the 5-HT2C receptor .
72] also found that suicide subjects who were receiving antidepressant treatment did not show any change in the level of BDNF, suggesting that psychotropic drugs normalize the decreased level of BDNF in suicide subjects and that BDNF may be a mediator of psychotropic drug action. Interestingly, Kozicz et al.  examined the sex difference in the expression of BDNF in suicide subjects. They found that the BDNF level was much lower in the midbrain of male suicide subjects, whereas female suicide subjects showed an increased level of BDNF in this brain area, suggesting a possible sex effect in the regulation of BDNF expression in suicide subjects.
J Affect Disord 2015; 174: 324–328. Neurotransmitter System and Suicide Kaschka WP, Rujescu D (eds): Biological Aspects of Suicidal Behavior. Adv Biol Psychiatry. 1159/000435768) 35 63 McNamara RK, Hyde TM, Kleinman JE, Lenox RH: Expression of the myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) in the prefrontal cortex and hippocampus of suicide victims. J Clin Psychiatry 1999; 60(suppl 2):21–26. 64 Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Roberts RC, Conley RR, Tamminga C: Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression.