By Pavel Koldovsky M. D. (auth.)
Interest within the common box of tumor immunology has grown phenomenally lately. The variety of courses con tinues to develop in doubtless exponential type and the tip isn't really but in sight. lower than those stipulations, it's very tricky for anyone investigator to understand the complete, or perhaps the small component in which his personal efforts needs to unavoidably be restrained. Weare therefore very lucky while an investigator with lengthy and large event within the box of tumor immunology takes the time to proportion his views of a element of that box. Dr. Koldovsky has been one of many pioneers in tumor immunology and he con tinues to give a contribution, in particular within the quarter of CEA. within the current survey he has reviewed the prestige of CEA, atmosphere forth not just the literature, yet his personal interpretation of that literature. For this activity, all staff in tumor immunology could be in reality grateful.
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Extra resources for Carcinoembryonic Antigens
The positive cases included 2 malignant teratoma and 4 hepatocellular carcinoma. Among the group with non-neoplastic diseases, AFP was detected only in children under 12 years of age with hepatopathies. In the positive cases, the level varied from 6-90 mg/mI of serum. Similarly, URIEL (1967) described AFP in sera of patients with hepatocellular carcinoma and ABELEV (1967) in some patients with hepatocellular and mixed liver carcinoma, and in patients with testicular teratoma. The radioimmunoassay is far more sensitive for detecting AFP than immunodiffusion, immunoelectrophoresis or immunofluorescence.
Control lymphocytes obtained from persons without cancer or with another type of cancer did not inhibit in-vitro growth of cells derived from intestinal adenocarcinomas or fetal intenstine. , 1970) that this antigen is probably different from the antigen described as cross-reacting between tumors of the digestive tract and embryonic intestinal tissue (GOLD and FREEMAN, 1965). The HELLSTROMS also reported that immune cells derived from pregnant women exhibited cytotoxic activity against such tumors.
In some experimental systems it was found that the level of soluble protein (albumin) necessary to maintain tolerance should be 10 ng/ml. So when the amount of CEA decreases sharply after birth or disappears completely, tolerance can disappear as well. Also unknown is the optimal dose necessary to induce tolerance against various antigens during embryogenesis and the relationship of this dose to the real level of CEA, which can, during embryogenesis, be introduced into the immunological apparatus of the developing embryo.