Download Neurology Volume 72(2) January 13, 2009 by American Academy of Neurology PDF

By American Academy of Neurology

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Stroke 1997;28:1614–1623. Anbeek P, Vincken KL, van Osch MJ, Bisschops RH, van der Grond J. Automatic segmentation of different-sized white matter lesions by voxel probability estimation. Med Image Anal 2004;8:205–215. Yoshita M, Fletcher E, Harvey D, et al. Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 2006;67:2192–2198. Jagust W. What can imaging reveal about obesity and the brain? Curr Alzheimer Res 2007;4:135–139. Haltia LT, Viljanen A, Parkkola R, et al.

Cognitive function in normal-weight, overweight, and obese older adults: An analysis of the Advanced Cognitive Training for Independent and Vital Elderly cohort. J Am Geriatr Soc 2006; 54:97–103. Elias MF, Elias PK, Sullivan LM, Wolf PA, D’Agostino RB. Obesity, diabetes and cognitive deficit: The Framingham Heart Study. Neurobiol Aging. 2005;26 Suppl 1:11–16. Arnold AM, Psaty BM, Kuller LH, et al. Incidence of cardiovascular disease in older Americans: the Cardiovascular Health Study. J Am Geriatr Soc 2005;53:211–218.

We also grouped women according to total ischemic lesion volume, which includes infarcts and WM signal abnormalities,17 using the cutpoint of Ͻ2 cm3 (lowest quartile) vs Ն2 cm3 (upper three quartiles). Analyses of covariance for total brain, ventricular, hippocampal, and frontal volumes were repeated using this grouping as a stratification factor to test the hypothesis that women with the lowest ischemic volume and the healthiest brains might show a benefit of HT on regional volumes. 1%) provided consent.

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